2,070 research outputs found
Searching for hidden mirror symmetries in CMB fluctuations from WMAP 7 year maps
We search for hidden mirror symmetries at large angular scales in the WMAP 7
year Internal Linear Combination map of CMB temperature anisotropies using
global pixel based estimators introduced for this aim. Two different axes are
found for which the CMB intensity pattern is anomalously symmetric (or
anti-symmetric) under reflection with respect to orthogonal planes at the
99.84(99.96)% CL (confidence level), if compared to a result for an arbitrary
axis in simulations without the symmetry. We have verified that our results are
robust to the introduction of the galactic mask. The direction of such axes is
close to the CMB kinematic dipole and nearly orthogonal to the ecliptic plane,
respectively. If instead the real data are compared to those in simulations
taken with respect to planes for which the maximal mirror symmetry is generated
by chance, the confidence level decreases to 92.39 (76.65)%. But when the
effect in question translates into the anomalous alignment between normals to
planes of maximal mirror (anti)-symmetry and these natural axes mentioned. We
also introduce the representation of the above estimators in the harmonic
domain, confirming the results obtained in the pixel one. The symmetry anomaly
is shown to be almost entirely due to low multipoles, so it may have a
cosmological and even primordial origin. Contrary, the anti-symmetry one is
mainly due to intermediate multipoles that probably suggests its
non-fundamental nature. We have demonstrated that these anomalies are not
connected to the known issue of the low variance in WMAP observations and we
have checked that axially symmetric parts of these anomalies are small, so that
the axes are not the symmetry ones.Comment: 18 pages, 10 figures, 2 tables. Consideration and discussion
expanded, 5 figures and 1 table added, main conclusions unchange
A Search for Correlation of Ultra-High Energy Cosmic Rays with IRAS-PSCz and 2MASS-6dF Galaxies
We study the arrival directions of 69 ultra-high energy cosmic rays (UHECRs)
observed at the Pierre Auger Observatory (PAO) with energies exceeding 55 EeV.
We investigate whether the UHECRs exhibit the anisotropy signal expected if the
primary particles are protons that originate in galaxies in the local universe,
or in sources correlated with these galaxies. We cross-correlate the UHECR
arrival directions with the positions of IRAS-PSCz and 2MASS-6dF galaxies
taking into account particle energy losses during propagation. This is the
first time that the 6dF survey is used in a search for the sources of UHECRs
and the first time that the PSCz survey is used with the full 69 PAO events.
The observed cross-correlation signal is larger for the PAO UHECRs than for 94%
(98%) of realisations from an isotropic distribution when cross-correlated with
the PSCz (6dF). On the other hand the observed cross-correlation signal is
lower than that expected from 85% of realisations, had the UHECRs originated in
galaxies in either survey. The observed cross-correlation signal does exceed
that expected by 50% of the realisations if the UHECRs are randomly deflected
by intervening magnetic fields by 5 degrees or more. We propose a new method of
analysing the expected anisotropy signal, by dividing the predicted UHECR
source distribution into equal predicted flux radial shells, which can help
localise and constrain the properties of UHECR sources. We find that the 69 PAO
events are consistent with isotropy in the nearest of three shells we define,
whereas there is weak evidence for correlation with the predicted source
distribution in the two more distant shells in which the galaxy distribution is
less anisotropic.Comment: 23 pages, version published in JCA
Short-term changes in ultrasound tomography measures of breast density and treatment-associated endocrine symptoms after tamoxifen therapy
Although breast density decline with tamoxifen therapy is associated with greater therapeutic benefit, limited data suggest that endocrine symptoms may also be associated with improved breast cancer outcomes. However, it is unknown whether endocrine symptoms are associated with reductions in breast density after tamoxifen initiation. We evaluated treatment-associated endocrine symptoms and breast density change among 74 women prescribed tamoxifen in a 12-month longitudinal study. Treatment-associated endocrine symptoms and sound speed measures of breast density, assessed via novel whole breast ultrasound tomography (m/s), were ascertained before tamoxifen (T0) and at 1-3 (T1), 4-6 (T2), and 12 months (T3) after initiation. CYP2D6 status was genotyped, and tamoxifen metabolites were measured at T3. Using multivariable linear regression, we estimated mean change in breast density by treatment-associated endocrine symptoms adjusting for age, race, menopausal status, body mass index, and baseline density. Significant breast density declines were observed in women with treatment-associated endocrine symptoms (mean change (95% confidence interval) at T1:-0.26 m/s (-2.17,1.65); T2:-2.12 m/s (-4.02,-0.22); T3:-3.73 m/s (-5.82,-1.63); p-trend = 0.004), but not among women without symptoms (p-trend = 0.18) (p-interaction = 0.02). Similar declines were observed with increasing symptom frequency (p-trends for no symptoms = 0.91; low/moderate symptoms = 0.03; high symptoms = 0.004). Density declines remained among women with detectable tamoxifen metabolites or intermediate/efficient CYP2D6 metabolizer status. Emergent/worsening endocrine symptoms are associated with significant, early declines in breast density after tamoxifen initiation. Further studies are needed to assess whether these observations predict clinical outcomes. If confirmed, endocrine symptoms may be a proxy for tamoxifen response and useful for patients and providers to encourage adherence
Associations between use of the 21‐gene recurrence score assay and chemotherapy regimen selection in a statewide registry
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/136480/1/cncr30429.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/136480/2/cncr30429_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/136480/3/cncr30429-sup-0001-suppinfo.pd
A public void catalog from the SDSS DR7 Galaxy Redshift Surveys based on the watershed transform
We produce the most comprehensive public void catalog to date using the Sloan
Digital Sky Survey Data Release 7 main sample out to redshift z=0.2 and the
luminous red galaxy sample out to z=0.44. Using a modified version of the
parameter-free void finder ZOBOV, we fully take into account the presence of
the survey boundary and masks. Our strategy for finding voids is thus
appropriate for any survey configuration. We produce two distinct catalogs: a
complete catalog including voids near any masks, which would be appropriate for
void galaxy surveys, and a bias-free catalog of voids away from any masks,
which is necessary for analyses that require a fair sampling of void shapes and
alignments. Our discovered voids have effective radii from 5 to 135 h^-1 Mpc.
We discuss basic catalog statistics such as number counts and redshift
distributions and describe some additional data products derived from our
catalog, such as radial density profiles and projected density maps. We find
that radial profiles of stacked voids show a qualitatively similar behavior
across nearly two decades of void radii and throughout the full redshift range.Comment: 13 pages, 10 figures, minor revisions and comparisons added, ApJ
accepted, public catalog available at http://www.cosmicvoids.ne
Disproportional Effects in Populations of Concern for Pandemic Influenza: Insights from Seasonal Epidemics in Wisconsin, 1967-2004
Influenza infections pose a serious burden of illness in the United States. We explored age, influenza strains, and seasonal epidemic curves in relation to influenza associated mortality
Bivariate genome-wide association meta-analysis of pediatric musculoskeletal traits reveals pleiotropic effects at the SREBF1/TOM1L2 locus
Bone mineral density is known to be a heritable, polygenic trait whereas genetic variants contributing to lean mass variation remain largely unknown. We estimated the shared SNP heritability and performed a bivariate GWAS meta-analysis of total-body lean mass (TB-LM) and total-body less head bone mineral density (TBLH-BMD) regions in 10,414 children. The estimated SNP heritability is 43% for TBLH-BMD, and 39% for TB-LM, with a shared genetic component of 43%. We identify variants with pleiotropic effects in eight loci, including seven established bone mineral density loci: _WNT4, GALNT3, MEPE, CPED1/WNT16, TNFSF11, RIN3, and PPP6R3/LRP5_. Variants in the _TOM1L2/SREBF1_ locus exert opposing effects TB-LM and TBLH-BMD, and have a stronger association with the former trait. We show that _SREBF1_ is expressed in murine and human osteoblasts, as well as in human muscle tissue. This is the first bivariate GWAS meta-analysis to demonstrate genetic factors with pleiotropic effects on bone mineral density and lean mass
Measurement of the Z/gamma* + b-jet cross section in pp collisions at 7 TeV
The production of b jets in association with a Z/gamma* boson is studied
using proton-proton collisions delivered by the LHC at a centre-of-mass energy
of 7 TeV and recorded by the CMS detector. The inclusive cross section for
Z/gamma* + b-jet production is measured in a sample corresponding to an
integrated luminosity of 2.2 inverse femtobarns. The Z/gamma* + b-jet cross
section with Z/gamma* to ll (where ll = ee or mu mu) for events with the
invariant mass 60 < M(ll) < 120 GeV, at least one b jet at the hadron level
with pT > 25 GeV and abs(eta) < 2.1, and a separation between the leptons and
the jets of Delta R > 0.5 is found to be 5.84 +/- 0.08 (stat.) +/- 0.72 (syst.)
+(0.25)/-(0.55) (theory) pb. The kinematic properties of the events are also
studied and found to be in agreement with the predictions made by the MadGraph
event generator with the parton shower and the hadronisation performed by
PYTHIA.Comment: Submitted to the Journal of High Energy Physic
Precise measurement of the W-boson mass with the CDF II detector
We have measured the W-boson mass MW using data corresponding to 2.2/fb of
integrated luminosity collected in proton-antiproton collisions at 1.96 TeV
with the CDF II detector at the Fermilab Tevatron collider. Samples consisting
of 470126 W->enu candidates and 624708 W->munu candidates yield the measurement
MW = 80387 +- 12 (stat) +- 15 (syst) = 80387 +- 19 MeV. This is the most
precise measurement of the W-boson mass to date and significantly exceeds the
precision of all previous measurements combined
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